they are the same wankers

elaborating on that. when you can hit a protein cleanly (without some side effects (called off-target, there are also on-target side effects)) but you hit wrong protein, this doesn’t have to be a complete loss, but it’s likely. maybe you learn something, either about biology of that all or about something else that it interacts with, or maybe you have found a cure to some other disease instead. but this is the actual hard problem of drug development, especially when the biology of it all is little known. there’s a few of these drugs that started this way, fentanyl, viagra, thalidomide (as anticancer), minoxidil come to mind, and at worst you have a new tool for biologists. alphafold won’t help with that

got you

i mean specifically this one

I don’t believe this says anything useful about Alphafold or Cryo structures because I just don’t believe these hit-rates. Anyone who reports 50% success from virtual screening has something very wrong with their assay. Before doing anything they should stick a pin in the catalogue 50 times, test those compounds, and when 25 of them come back active they should stop and work out why.

The rest of criticisms is in article

also note it’s from january so not about the new thing

also note that the big failures come from faulty biology, not from faulty chemistry. You can set innumerable piles of cash on fire if you choose to plug a wrong enzyme

if you’re using firefox, disable enhanced tracking protection to see disqus comments

this sounded weird so i looked it up, and it seems to be a sort of mistranslation, iranian soldiers were given a booklet of pamphlets called “Keys to Paradise” along their dogtags https://en.wikipedia.org/wiki/Plastic_key_to_paradise

it does seem mildly useful https://www.science.org/content/blog-post/screening-against-alphafold-models-maybe-better-it-looks

note that google’s thing is pattern matching, and if there’s few similar protein structures in literature, then alphafold is working on poor quality data. comments do notice a red flag or two

from few encounters it really seems like he dips into the void for weeks randomly. after he wanted to have something explained over matrix he didn’t reply for like two four months. really taking instant out of instant messaging

legally, that’s not news

at least crypto isn’t involved this time. few understand (real world economics)

it sounds like what they’re trying to do is Wada test, for no particular reason, with zero knowledge what they’re trying to do or what tools do they need for that

about everything what could they learn from that is already described in psychiatry and psychology textbooks, but it’s too hard for homeschooled first-principlers like them

that’s a very carefully worded comment. there’s a reason why benzos were commonly prescribed in the past (but less so now)

it’s a known issue https://en.m.wikipedia.org/wiki/Kindling_(sedative–hypnotic_withdrawal)

this is peak 18-century science

we have mkultra at home

on the other hand, that’s just speedrunning being jordan peterson

on the third hand, our very good friend apparently never had been drunk

on the fourth hand, our very good friend also didn’t clock that maybe his ability to assess his own mental state was disturbed (it was) (severely)

on the fifth hand, this is an effect of many drugs, iv line suggests midazolam but maybe ketamine was an option. neither are exactly easily available for regular civilian (other benzos are)

first principling that benzos are completely safe, yeah way to go, 10/10. also not their first rodeo, but lwers on drugs would be megaminds on adderal, at least that’s what could be noticed previously

planck length doesn’t come up even once, it all boils down to these things: 1. electron has momentum, and from that follows it has a wavelength, and at the same time 2. orbit is stable, which means that after every “rotation” electron has to end up with the same phase, which means there is only a finite number of solutions to time-independent schroedinger equation for (hydrogen) atom (don’t bother solving it on paper for anything with more than one electron) and these things are spherical harmonics

that only works outside of dead internet

drop one in kaliningrad plz

these are f orbitals, there is 5 of d orbitals