Dude have you seen how many diet Cokes people drink? Liters and liters daily. Not excessive at all honestly considering LifeTime total exposure
Im a chemist by trade. This is actually chemically very simple. I only looked deeply into Sucralose Splenda. So I’ll discuss that
These have Chlorine molecules. A very electrophilic element even in a chemical bond. Meaning it can cause reactions in other molecules very easily. Sucralose has Three Chlorines. If it touches DNA it’s bad business man.
I love diet Coke btw lol I could drink 5 gallons right now idk I smoke cigs. But don’t sugar coat it
You are saying that sucralose (or a metabolite thereof) could alkylate DNA - and theoretically proteins too - correct? Like what sulfur mustard gas does?
I did a quick search and couldn’t find any papers demonstrating a mechanism of action for that, although I skimmed a few that postulated that a dichlorinated hydrolysis product might be the true carcinogenic agent. Do you know of any studies that demonstrate that the alkylation can happen, either in vitro or (ideally) in vivo? Or maybe some better search terms to use, that could be my issue…
I am truly curious about this, I never knew the chemical structure of sucralose until I read your comment and subsequently looked it up.
Dude have you seen how many diet Cokes people drink? Liters and liters daily. Not excessive at all honestly considering LifeTime total exposure
Im a chemist by trade. This is actually chemically very simple. I only looked deeply into Sucralose Splenda. So I’ll discuss that
These have Chlorine molecules. A very electrophilic element even in a chemical bond. Meaning it can cause reactions in other molecules very easily. Sucralose has Three Chlorines. If it touches DNA it’s bad business man.
I love diet Coke btw lol I could drink 5 gallons right now idk I smoke cigs. But don’t sugar coat it
You are saying that sucralose (or a metabolite thereof) could alkylate DNA - and theoretically proteins too - correct? Like what sulfur mustard gas does?
I did a quick search and couldn’t find any papers demonstrating a mechanism of action for that, although I skimmed a few that postulated that a dichlorinated hydrolysis product might be the true carcinogenic agent. Do you know of any studies that demonstrate that the alkylation can happen, either in vitro or (ideally) in vivo? Or maybe some better search terms to use, that could be my issue…
I am truly curious about this, I never knew the chemical structure of sucralose until I read your comment and subsequently looked it up.