Shamelessly copied from https://reddit.com/comments/11fvkw7

OP had success with deleting and recreating the proton folder, and it helped for me too. (Remember to backup your saves!) Also ProtonGE / Glorious Eggroll does seem to work better than vanilla Steam Proton. I have not tried using the plugin loader

You could also try backing up your wine prefix, and then delete it and get steam to regenerate it. This is because sometimes it gets messed up, and not fixed when validating game files or reinstalling the game. It’s important to back it up though, since it’s where all your saves and workshop items are stored. It’s at ~/.steam/steam/steamapps/compatdata. The folder name is 244850. Once you’ve done this, go to {prefix folder}/244850/pfx/drive_c/users/steamuser/Application Data/, and replace the SpaceEngineers folder in the newly generated prefix with the one in the backup (keep hold of the backup though just in case).

There’s also some troubleshooting steps in https://www.protondb.com/app/244850, generally I find that randomly copypasting some of the launch options and suggestions from here helps fix a few issues - but don’t do the ‘protontricks 244850 --force dotnet48’ It used to be the only way to get SE to run

Another thing you could try is installing the plugin loader (which surprisingly works on linux) and enabling some of the performance improvements plugins. I haven’t firsthand seen any crashes been fixed from this, but it’s worth a try, and some of the plugins are worth having in general.

Also: If you add -skipintro (after the %command%) in the steam launch options, you don’t have to manually go in and delete the video files.